Spindle cell angiosarcoma as primary cutaneous tumor - case report and brief literature review

Andreea Cătălina Tinca; Bianca Andreea Lazar; Carmen Beatrice Friciu; Ovidiu Simion Cotoi

doi:10.2478/amma-2025-0012

Andreea Cătălina Tinca Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania
Bianca Andreea Lazar Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania
Carmen Beatrice Friciu Plastic Surgery Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania
Ovidiu Simion Cotoi Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania

DOI: https://doi.org/10.2478/amma-2025-0012

Keywords: angiosarcoma, rare, immunohistochemistry

Abstract

Angiosarcoma is a rare, aggressive malignant tumor of vascular origin, often characterized by rapid growth and infiltrative behavior. While it commonly occurs in the skin, particularly on the scalp of elderly patients, it can also affect other regions. We present a case of a 76-year-old male with a rapidly growing, well-demarcated nodule on the dorsum of the hand, which was excised for pathological examination. Histopathological analysis revealed spindle-shaped tumoral cells with a storiform pattern, poor vascularization, and immunohistochemistry positivity for CD31 and CD34. The case underscores the importance of distinguishing angiosarcoma from other spindle-cell tumors, such as leiomyosarcoma and atypical fibroxanthoma, and highlights the essential role of immunohistochemistry in achieving an accurate diagnosis. Early detection and appropriate surgical management are crucial for optimal outcomes in patients with this aggressive malignancy.