Soy polysaccharides therapeutic and technological aspects

  • Robert-Alexandru Vlad Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade" din Târgu Mureș
  • Paula Antonoaea
  • Emoke Margit Redai
  • Daniela-Lucia Muntean
  • Nicoleta Todoran
  • Magdalena Bîrsan
  • Anamaria Tataru
  • Adriana Ciurba
Keywords: soy polysaccharides, excipient, superdisintegrant, colon drug delivery, therapeutic effect

Abstract

Abstract

Soy polysaccharides represent a multipurpose class of chemicals that include both therapeutical and technological properties. Since they have been first time introduced in the pharmaceutical field, Soy polysaccharides were used in two different pharmaceutical formulations; sublingual tablets and in colon drug delivery. For the sublingual tablets, Soy polysaccharides under the brand name of Emcosoy© - were used as a superdisintegrant in concentrations between 4-8% showing comparable results with the artificial superdisintegrants (sodium starch glycolate, sodium croscarmellose, and polyvinylpyrrolidone). The second technological field where Soy polysaccharides were used is represented by colon drug delivery where it was used in combination with ethylcellulose showing a prolonged lag time compared to the results found in the literature. The medicinal effect of these polysaccharides consists of treating diarrhea. As it will be presented in the article, these chemical compounds tend to decrease the aqueous stool time in patients with diarrhea and to conduct to a softer stool in healthy patients. In conclusion, these polysaccharides present multiple purposes possessing a medicinal effect and also the possibility of being used as a double-faceted pharmaceutical excipient.

Keywords: soy polysaccharides, excipient, superdisintegrant, colon drug delivery, therapeutic effect

Published
2021-11-15
How to Cite
1.
Vlad R-A, Antonoaea P, Redai EM, Muntean D-L, Todoran N, Bîrsan M, Tataru A, Ciurba A. Soy polysaccharides therapeutic and technological aspects. amm [Internet]. 15Nov.2021 [cited 28May2022];67(4). Available from: https://ojs.actamedicamarisiensis.ro/index.php/amm/article/view/86