Beyond the Gut - Atypical Presentation of Salmonella spp. Infection

  • Anca Cighir Department of Microbiology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
  • Corina Eugenia Budin Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mures
  • Teodora Cighir Mureș Clinical County Hospital
  • Anca Delia Mare Department of Microbiology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
  • Adrian Man Department of Microbiology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Keywords: pleural empyema, Salmonella, extraintestinal salmonellosis

Abstract

Salmonella is a Gram-negative, non-spore-forming, motile, facultative anaerobic rod. The most studied species are Salmonella typhi and paratyphi (causing typhoid fever) and non-typhi Salmonella species (which can cause different clinical syndromes - gastroenteritis, disseminated infections, etc.).

       A 61-year-old male patient with multiple comorbidities (including myelofibrosis) presented to the Pulmonology outpatient department, Clinical County Hospital of Târgu Mureș, with a mucopurulent nocturnal cough. Paraclinical examinations showed the presence of a pleural empyema, which was evacuated in local anesthesia. The pleural fluid was sent to the Microbiology Department for bacteriological testing, where a fluoroquinolone-resistant strain of Salmonella spp. was detected. The patient received antibiotic treatment according to the antibiotic susceptibility testing. Due to the persistence of the symptoms, the patient returned two weeks later, when another puncture was performed. Salmonella was isolated again, but the strain showed a higher resistance to antibiotics. The two strains were compared using molecular methods of diagnosis (ERIC-PCR), the results showing a similarity of 92%. The occurrence of an extra amplicon band in ERIC-PCR suggests an important change in the bacterial genetic material, potentially related to acquisition of antibiotic resistance factors.

Published
2024-05-29
How to Cite
1.
Cighir A, Budin CE, Cighir T, Mare AD, Man A. Beyond the Gut - Atypical Presentation of Salmonella spp. Infection. amm [Internet]. 29May2024 [cited 21Jul.2024];70(2). Available from: https://ojs.actamedicamarisiensis.ro/index.php/amm/article/view/529
Section
Original article