SARS-CoV2 Infection in a Multiple Sclerosis Patient Treated with Natalizumab – A Case Presentation

  • Georgiana Șerban Neurology Clinic 1, Emergency Clinical County Hospital of Târgu Mureș
  • Rodica Bălașa Neurology Clinic 1, Emergency Clinical County Hospital of Târgu Mureș; Neurology Department, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology of Târgu Mureș
Keywords: multiple sclerosis, Natalizumab, SARS-CoV2 infection, COVID-19 outbreak

Abstract

Introduction: The novel coronavirus, SARS-CoV2, has rapidly spread worldwide and led to an intense collaboration among both physicians and researchers in order to stop its dissemination. Little is yet known about how this virus behaves, but recent studies have suggested the role of integrins in the viral penetration of target cells. Natalizumab is an anti-α4-β1 integrin monoclonal antibody used in the treatment of multiple sclerosis (MS), a neurodegenerative auto-immune disease affecting primarily young adults. MS patients have a greater susceptibility to develop severe infections especially enhanced by the disease-modifying therapies (DMTs) which are currently recommended for their treatment. Natalizumab is considered the safest high-efficacy DMT in times of COVID-19 outbreak. Case presentation: We hereby describe the first case from Romania of a MS patient treated with Natalizumab who subsequently acquired SARS-CoV2 infection and whose recovery was excellent, with no functional neurological or respiratory sequelae. Conclusion: The favourable evolution of our patient supports the potential therapeutic effect Natalizumab might have in SARS-CoV2 treatment by specifically blocking integrins and by its immunosuppressant characteristics.

Published
2020-09-03
How to Cite
1.
Șerban G, Bălașa R. SARS-CoV2 Infection in a Multiple Sclerosis Patient Treated with Natalizumab – A Case Presentation. amm [Internet]. 3Sep.2020 [cited 25Nov.2020];66(3):110-2. Available from: https://ojs.actamedicamarisiensis.ro/index.php/amm/article/view/34
Section
Case report