Development of semisolid pharmaceutical forms with mometasone furoate

  • Emőke Margit Rédai UMFST
  • Boglárka Jakab
  • Robert Alexandru Vlad 1 Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Targu Mures
  • Paula Antonoaea 1 Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Targu Mures
  • Nicoleta Todoran 1 Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Targu Mures
  • Emese Sipos Department of Industrial Pharmacy and Management, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Targu Mures
  • Adriana Ciurba 1 Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Targu Mures
Keywords: mometasone furoate, hydrogel, diffusion, dermal administration

Abstract

Objective This study aims to develop semisolid pharmaceutical forms for the topical administration of mometasone furoate.
Methods Two creams (O1 and O2) and four hydroxypropyl methylcellulose-based hydrogels were prepared (H3-H6). Two different sorts of hydroxypropyl methylcellulose were used in concentrations of 15 and 20%. Consistency, spreadability, viscosity, and pH were measured. In vitro drug release was determined by a vertical diffusion cell. Mathematical models were applied for a better understanding of release phenomena.
Results O1 and O2 presented lower values for penetration depth and spreadability. Hydrogel viscosity is influenced by the type and concentration of the gel-forming agent. Viscosity decreases in the order H6, H5, H4, and H3. pH varies between 4.6 to 5.92, fulfilling the requirements of European Pharmacopiea. Creams showed 5.49 and 6.59% of mometasone released after 6 hours. The lowest viscosity hydrogel presented the best dissolution of 40.11% mometasone after 6 hours.
Conclusions H3 hydrogel releases the highest amount of mometasone furoate after 6 hours. The release is best described by the Korsmeyer-Peppas model explained by water diffusion and polymeric chain relaxation happen during the swelling of the polymer.

Published
2023-11-13
How to Cite
1.
Rédai EM, Jakab B, Vlad RA, Antonoaea P, Todoran N, Sipos E, Ciurba A. Development of semisolid pharmaceutical forms with mometasone furoate. amm [Internet]. 13Nov.2023 [cited 23Apr.2024];69(4). Available from: https://ojs.actamedicamarisiensis.ro/index.php/amm/article/view/213
Section
Original article