Is the pulmonary microbiome involved in lung cancer pathophysiology?

  • Corina Eugenia Budin George Emil Paalade University of Medicine, Pharmacy, Science and Technology of Targu Mures
  • Iuliu Gabriel Cocuz George Emil Paalade University of Medicine, Pharmacy, Science and Technology of Targu Mures
  • Hédi Katalin Sárközi George Emil Paalade University of Medicine, Pharmacy, Science and Technology of Targu Mures
  • Adrian Horatiu Sabau George Emil Paalade University of Medicine, Pharmacy, Science and Technology of Targu Mures
  • Bianca Liana Grigorescu George Emil Paalade University of Medicine, Pharmacy, Science and Technology of Targu Mures
Keywords: microbiome, lung cancer, microbiome, genetic alterations

Abstract

Bronchopulmonary cancer represents the neoplasms associated with the highest mortality rate, despite diagnostic and therapeutic advances in recent decades. Early diagnosis is often difficult due to the paucity of symptoms or superinfections. Screening subjects at risk of developing lung cancer include clinical, bacteriological, inflammatory status, and genetic profile assessment. The personal microbiome has an essential role in the physiology of the human body. The gut-lung axis plays an essential role in carcinogenesis, being involved in various pathways. The lung microbiome can contribute to the development of lung cancer either directly by acting on tumor cells or indirectly by modulating the tumor-associated immune response. The gut microbiome can directly affect the response to immunotherapy in patients with non-small cell lung cancer.

 

Keywords: microbiome, lung cancer, microbiome, genetic alterations.

Author Biographies

Corina Eugenia Budin, George Emil Paalade University of Medicine, Pharmacy, Science and Technology of Targu Mures

Department of Pathophysiology, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Romania

Hédi Katalin Sárközi, George Emil Paalade University of Medicine, Pharmacy, Science and Technology of Targu Mures

Department of Pulmonology, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Romania

Adrian Horatiu Sabau, George Emil Paalade University of Medicine, Pharmacy, Science and Technology of Targu Mures

Department of Pathophysiology, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Romania

Bianca Liana Grigorescu, George Emil Paalade University of Medicine, Pharmacy, Science and Technology of Targu Mures

Department of Anesthesia and Intensive Care, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Romania

Published
2022-09-13
How to Cite
1.
Budin C, Cocuz I, Sárközi H, Sabau A, Grigorescu B. Is the pulmonary microbiome involved in lung cancer pathophysiology?. amm [Internet]. 13Sep.2022 [cited 6Dec.2022];68(3). Available from: https://ojs.actamedicamarisiensis.ro/index.php/amm/article/view/173