Insulin resistance as risk factor for the development of type 2 diabetes mellitus: a systematic approach

  • Reka Annamaria Schmiedt Compartment of Diabetology, Emergency Clinical County Hospital of Targu Mures, Romania
  • Robert Aurelian Tiuca Department of Endocrinology, Mures County Clinical Hospital, Târgu Mureș, Romania; "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures
  • Raluca Maria Tilinca "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
  • Lucia Mihaela Custura Compartment of Diabetology, Emergency Clinical County Hospital of Targu Mures, Romania
  • Oana Detesan Compartment of Diabetology, Emergency Clinical County Hospital of Targu Mures, Romania
  • Brigitta Iren Bacso Compartment of Diabetology, Emergency Clinical County Hospital of Targu Mures, Romania
  • Bianca Larisa Abalasei "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
  • Andrew Corneliu Bell "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
  • Maria Alexandra Streza "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
  • Mariana Cornelia Tilinca Compartment of Diabetology, Emergency Clinical County Hospital of Targu Mures, Romania; "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures
Keywords: insulin resistance, type 2 diabetes, obesity, cytokines, risk factor

Abstract

Insulin resistance is a heterogenous condition with high prevalence in medical practice. As diabesity reaches epidemic levels worldwide, the role of insulin resistance is getting great importance. Contribution of risk factors like sedentary lifestyle, diets high in saturated fats and refined carbohydrates leads to this state with significant consequences. Besides its role in diabetes, insulin resistance is also associated with other several endocrine diseases, having not only a role in their development, but also to their treatment approach, evolution and even prognosis. The present review summarizes the current literature on the clinical significance of insulin resistance, as well as the possible underlying mechanisms and treatment options in order to achieve a high quality of life of these categories of patients. Deepening the role of inflammatory cytokines involved in insulin resistance paves the way for future research findings in this continuously evolving field.

Published
2021-10-22
How to Cite
1.
Schmiedt R, Tiuca R, Tilinca R, Custura L, Detesan O, Bacso B, Abalasei B, Bell A, Streza M, Tilinca M. Insulin resistance as risk factor for the development of type 2 diabetes mellitus: a systematic approach. amm [Internet]. 22Oct.2021 [cited 28May2022];67(4). Available from: https://ojs.actamedicamarisiensis.ro/index.php/amm/article/view/107